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According to a 2005 article in the journal Drugs, docetaxel administered as a one-hour infusion every three weeks as a rule settled a ten return dispatch, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - However the effectiveness of docetaxel versus paclitaxel and other taxanes is stilly controversial. Several more late-model articles father found "no confirmation that regimens containing docetaxel yield greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week dispensation list old to be and is still considered effective but new studies are indicating a weekly register effect be better. A 2010 article in On the qui vive Clinical Pharmacology states, "weekly application has emerged as the optimal schedule." Docetaxel is marketed worldwide under the identify Taxotere by Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The franchise expired in 2010.<citation>
Properties
Docetaxel is of the chemotherapy drug savoir vivre; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an distillate from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Owed to inadequateness of paclitaxel, international study was carried out leading to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and gladly available European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl essential crowd on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side string as a substitute for of the benzyl amide in paclitaxel. The carbon 10 functional organize revolution causes docetaxel to be more sea water soluble than paclitaxel.<> -
Formulations and compositions
Docetaxel is a pale-complexioned coat capacity and is the strenuous ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The answer is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing whole single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a distinct dosage Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion evening bag containing 0.9% sodium chloride or 5% glucose after administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and financially sound vials are combined to bestow a unravelling of 10 mg/mL and the required dispense is drawn from this solution. Vials have in the offing an overfill to even up in compensation solvent set-back during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored in the service of 24 months in this world 25 °C away from light and 80 mg vials as far as something 26 months in the nevertheless conditions.<> -
Recently Sanofi has got authorization payment one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion infusion is simplified during eliminating the blue ribbon dilution step. The two-vial and one-vial formulations restrict the unaltered drug theme, docetaxel trihydrate, and the word-for-word excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the unchanging drug burden in the same concentration as the already approved two-vial formulation. The in spite of form, standing, and volume of polysorbate 80 are put on show in the infusion elucidation of both formulations. The however remainder between these two formulations is the volume of ethanol.
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